Multiple offices at the US Department of Energy (DOE) are working to ensure availability of the critical minerals and materials (CMM) required for the clean energy transition. This includes research, development, demonstration, and deployment (RDD&D) projects which will establish environmentally responsible, equitable, resilient, and secure domestic critical mineral supply chains. DOE’s priorities revolve around diversifying supply, developing substitutes, and ensuring reuse/recycling, with efforts covering the full spectrum from basic science to commercialization. This includes working closely with the USGS and state agencies in identifying and characterizing resources throughout the U.S; it also includes developing resource maps and designing targeted extraction technologies for unique, unconventional and secondary sources (e.g., coal ash and refuse, mine wastes, geothermal brines and produced waters, steelmaking wastes and byproducts etc). It also includes developing and advancing the technologies needed to responsibly and cost effectively recover critical minerals from recycled batteries and other electronic equipment. In this talk we will outline DOE’s strategy and approach, give examples of current efforts and results, and provide a look at future priorities and opportunities.