Well diagnostics in deep, offshore GoM are vital in order to interpret any issues related to productivity losses. This is especially important since any intervention in such wells is very costly. Multiphase flow is amongst leading causes of well productivity loss. This presentation shares an integrated workflow that provides a solution to the challenge of quantifying multiphase PTA results in single and multiple commingled production cases. The workflow is used to monitor the performance of several wells over an extended period in a deep-water offshore reservoir under water/aquifer drive. It builds on a succession of PTA tests starting from single phase flow until water breakthrough and beyond. The results of historical PTA provided meaningful insights that were used as basis for actions that led to well and reservoir performance optimization.