Modern wireline formation testers are capable of providing a wide range of downhole rock and fluid properties at in-situ reservoir conditions and can help identify subtleties such as compartmentalization and compositional grading. Increasingly more massive and complex strings are being run to obtain a wealth of information under ever more challenging conditions. Even in developed reservoirs, unexpected circumstances arise, requiring immediate response and modifications to the pre-planned job procedures.  Unexpectedly low or high mobilities, probe plugging, unanticipated fluid types, presence of multiple phases, and excessive fluid contamination are but a few examples of such circumstances that would require real-time decision making and procedural modifications. Real-time decisions may include acquiring more pressure data points, extending sampling depths to several zones, extending or shortening sampling times, repeating micro-hydraulic fracture re-opening/closure cycles, real-time permeability interpretation, and determination of optimum flow/buildup durations.